Sequential Functional and Morphological Alterations During Hepatocarcinogenesis Induced in Rats by Feeding of a Low Dose of 2-Acetylaminofluorene
نویسندگان
چکیده
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
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15 صفحه اولReduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
The effects of dietary phénobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The simultaneous feeding of AAF and phénobarbital reduced the hepatocarcinogenic effects of AAF. In contrast, the sequential feeding of AAF and phénobarbital resulted in a significant increase in the incidence of hepatomas. No ill effects were observed in rats fed phénobarbital...
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nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...
15 صفحه اولQuantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
nodules (14, 29). These in turn may derive from smaller microscopic foci of modified hepatocytes referred to as islands (10, 30, 32). Many of the islands, nodules, and carcinomasshow similar features including increased rates of cell division (23, 27) and altered bevelsof enzymes (6, 8, 9, 12, 15, 16, 30). For determination of whether any corre lation exists between rates of cell replication an...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1994
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339402200606